Value of NT-proBNP,IFN-γ and NO in the diagnosis and prognosis evaluation of severe hand-foot-mouth disease
Aim To explore the application value of N-terminal pro-brain natriuretic peptide(NT-proBNP),interferon-γ(IFN-γ)and nitric oxide(NO)in the diagnosis and prognosis evaluation of severe hand-foot-mouth disease.Methods A total of 224 children with hand-foot-mouth disease were enrolled.According to disease severity,they were divided into mild group and severe group.A total of 30 healthy children during the same period were enrolled as control group.According to prognosis results,chil-dren in severe group were divided into survival group and death group.The levels of serum NT-proBNP,IFN-γ and NO in different groups were compared.The value of NT-proBNP,IFN-γ and NO in the diagnosis and prognosis prediction of severe hand-foot-mouth disease was analyzed by ROC curves.Using Logistic regression to analyze the influencing factors of prognosis for severe hand,foot,and mouth disease.Results The levels of serum NT-proBNP,IFN-γ and NO were gradually decreased in severe group,mild group and control group.The levels of serum NT-proBNP,IFN-γ and NO in death group were higher than those in survival group(P＜0.05).In death group,death rate in patients with oxygen saturation＜90％was higher than that of patients with oxygen satura-tion ≥90％.The combined detection of serum NT-proBNP,IFN-γ and NO was of good value in the diagnosis and prognosis predic-tion of severe hand-foot-mouth disease(P＜0.05).The high expressions of serum NT-proBNP,IFN-γ and NO are risk factors of poor prognosis in children with severe HFMD,while oxygen saturation＜90％was a protective factor of good prognosis.Conclusion The levels of serum NT-proBNP,IFN-γ and NO are increased in children with severe HFMD,and combined detection of the three indexes is of great value in the diagnosis and prognosis evaluation of HFMD.
万方数据
维普
