Effect of different doses of cytarabine combined with antibiotics on serum MCP-1 and CCR-2 levels in children with leukemia
Aim To investigate the effect of cytarabine combined with antibiotics on serum monocyte chemoattractant protein-1(MCP-1)and CC chemokine receptor-2(CCR-2)levels in children with acute myeloid leukemia.Methods 96 chil-dren with acute myeloid leukemia were selected and divided into observation group(n=48)and control group(n=48)according to the treatment scheme,that the observation group was given high-dose cytarabine combined with deoxyrubicin,while the control group was given conventional dose of cytarabine combined with deoxyrubicin.The therapeutic efficacy and adverse reactions of the two groups were observed,the serum MCP-1 was detected by ELISA,and the expression of CCR-2 on monocytes was detected by flow cy-tometry cell analysis.Results The CR rate of the observation group was higher than that of the control group(P＜0.05).The incidence of pathogenic bacteria infection in the observation group was significantly lower than that in the control group(P＜0.05).There was no significant difference in adverse reactions(P＞0.05).The serum MCP-1 and CCR-2 levels in the observation group af-ter treatment were significantly lower than those in the control group(P＜0.05).Conclusion The high-dose cytarabine combined with doxorubicin has a significant therapeutic effect on children with acute myeloid leukemia,which could significantly reduce the ser-um levels of MCP-1 and CCR-2.
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