High mobility group box-1 protein(HMGB1)is a highly conserved nuclear protein involved in transcription,repli-cation,DNA repair,and nucleosome assembly in the nucleus.Extracellular HMGB 1 acts as an alarm protein involved in various in-flammatory responses and autoimmunity.Neutrophilic asthma(NA)is a neutrophilic inflammation of the airway driven by non-type 2 inflammatory factors,but effective treatments are currently lacking.Studies have shown that HMGB 1 has some clinical values in the diagnosis and treatment of neutrophilic asthma and may be a potential therapeutic agent for neutrophilic asthma.This review summari-zes the structure and function of HMGB1,its interaction with receptor,and advances in the targeted therapy of neutrophilic asthma,to facilitate the research for new effective therapeutic agents for neutrophilic asthma.
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