Progress in targeting HMGB1 for the treatment of neutrophilic asthma
High mobility group box-1 protein(HMGB1)is a highly conserved nuclear protein involved in transcription,repli-cation,DNA repair,and nucleosome assembly in the nucleus.Extracellular HMGB 1 acts as an alarm protein involved in various in-flammatory responses and autoimmunity.Neutrophilic asthma(NA)is a neutrophilic inflammation of the airway driven by non-type 2 inflammatory factors,but effective treatments are currently lacking.Studies have shown that HMGB 1 has some clinical values in the diagnosis and treatment of neutrophilic asthma and may be a potential therapeutic agent for neutrophilic asthma.This review summari-zes the structure and function of HMGB1,its interaction with receptor,and advances in the targeted therapy of neutrophilic asthma,to facilitate the research for new effective therapeutic agents for neutrophilic asthma.
万方数据
维普
