摘要
线粒体是动态且高度可塑的细胞器,是细胞的能量工厂,具有调控细胞内能量生成、代谢以及信号转导的作用.研究表明,线粒体调控细胞增殖、凋亡、衰老、分化、细胞周期等与细胞命运密切相关的生物学过程,表明线粒体在调控细胞命运过程中发挥着重要的生物学作用.本文综述了线粒体能量代谢、线粒体蛋白、活性氧、线粒体DNA、线粒体动力学调控细胞命运的机制,以期为细胞命运的调控提供新的策略和靶点.
Abstract
Mitochondria are dynamic and highly plastic organelles,and are the energy factories of cells,playing a role in regu-lating intracellular energy generation,metabolism,and signal transduction.Researches have shown that mitochondria regulate many biological processes,such as proliferation,apoptosis,aging,differentiation,and cell cycle,indicating that mitochondria play an im-portant biological role in regulating cell fate.This article reviews the mechanisms by which mitochondrial energy metabolism,mito-chondrial proteins,reactive oxygen species,mitochondrial DNA,and mitochondrial dynamics regulate cell fate,in order to provide new strategies and targets for the regulation of cell fate.
基金项目
南华大学大学生创新项目(202110555091)
维普
万方数据