Effects of argatroban on blood lipids,inflammatory markers,and neurological function in patients with acute cerebral infarction complicated with hyperhomocysteinemia
Aim To investigate the impact of argatroban on lipid profiles,inflammatory markers,and neurological function in acute cerebral infarction patients with hyperhomocysteinemia(HHcy).Methods A total of 140 acute cerebral infarction pa-tients with HHcy were selected and randomly divided into two groups,namely the control group(standard treatment)and the observa-tion group(argatroban+standard treatment).We analyzed plasma homocysteine(Hcy),hyper-sensitivity C-reactive protein(hs-CRP),high density lipoprotein cholesterol(HDLC),low density lipoprotein cholesterol(LDLC),total cholesterol(TC),triglycerides(TG),national institutes of health stroke scale(NIHSS)scores,Barthel index scores,prothrombin time(PT),and acti-vated partial thromboplastin time(APTT).We then analyzed the correlation between Hcy,hs-CRP,HDLC,LDLC,TC,TG,NIHSS scores,and Barthel index before treatment.Results Compared with the pre-treatment levels,post-treatment levels of Hcy,hs-CRP,LDLC,and TC were decreased in both groups,with the observation group showing significantly lower levels than the control group(P＜0.05).PT and APTT returned to normal ranges by day 5 in the control group and by day 3 in the observation group.PT and APTT were significantly higher in the observation group than in the control group on days 2-4(P＜0.05),but no significant differ-ences were observed between the two groups on days 6-7(P＞0.05).NIHSS scores were decreased and Barthel index scores were in-creased on days 7,30,and 90 in both groups compared with those on day 1,with more significant improvements in the observation group(P＜0.05).Hey,hs-CRP,and LDLC levels were positively correlated with NIHSS scores and negatively correlated with Barthel index scores(P＜0.05).Conclusion Argatroban significantly reduces lipid levels,Hcy,and inflammation in acute cerebral infarc-tion patients with HHcy,improves coagulation function,and accelerates the recovery of neurological function and daily living activities.
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