The predictive values of changes in inflammatory factors during pregnancy for preeclampsia in patients with gestational hyperglycemia
Aim To analyze the predictive values of changes in inflammatory factors during pregnancy for preeclampsia(PE)in patients with gestational hyperglycemia.Methods 202 patients with gestational hyperglycemia were selected and divided into PE group(n=49)and a control group(n=153)based on PE occurrences.The pregnancy outcomes,fasting blood glucose,glycosylated hemoglobin,fasting insulin(FIN),homeostasis model assessment-insulin resistance index(HOM A-IR)and the serum inflammatory factor levels between the two groups were compared.The Logistic regression was used to analyze the influencing factors of gestational hyperglycemia combined with PE,and the predictive value of inflammatory factors on PE were analyzed by ROC.Results Compared with the control group,the neonatal Apgar score and gestational age in the PE group were decreased,while the proportion of premature rupture of membranes,postpartum hemorrhage,postpartum fever,premature infants,fetal distress,fetal hypo-glycemia,FIN,HOMA-IR,and serum inflammatory factor levels were increased(P＜0.05).Serum inflammatory factors were the risk factor for the occurrence of PE,and the AUC of PE predicted by the levels of the same inflammatory factors in mid pregnancy was higher than that in early pregnancy.Serum tumor necrosis factor alpha(TNF-α)levels predicted the highest AUC of PE,and the sensitivity and specificity of TNF-α levels during mid pregnancy in predicting PE were 79.59％and 96.08％,respectively.Con-clusion The patients with gestational hyperglycemia complicated with PE can exhibit elevated levels of serum pro-inflammatory factors,which may be related to the degree of insulin resistance.The detection of serum levels of inflammatory factors has an auxilia-ry value in predicting the occurrence of PE.
万方数据
维普
