摘要
目的 评估帕罗西汀联合喹硫平治疗双相情感障碍(BPD)抑郁发作的临床疗效.方法 选取100例BPD抑郁发作患者,随机均分为对照组(帕罗西汀)、观察组(帕罗西汀+喹硫平).比较两组治疗有效率、汉密尔顿抑郁量表-17(HAMD-17)评分、抑郁水平评定量表(CES-D)评分、炎症因子、生活质量综合评定问卷(GQOLI-74)评分、药物不良反应率.结果 观察组治疗有效率高于对照组(P＜0.05).治疗6周后,观察组H AMD-17评分、CES-D评分、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1降低,IL-10、GQOLI-74评分升高(P＜0.05),且观察组改善优于对照组(P＜0.05).两组药物不良反应无差异.结论 BPD抑郁发作患者采用帕罗西汀联合喹硫平治疗,可以改善TNF-α、IL-1、IL-10水平,增强疗效,缓解抑郁情绪.
Abstract
Aim To evaluate the clinical efficacy of paroxetine plus quetiapine in patients with bipolar disorder(BPD)de-pressive episodes.Methods 100 patients with BPD depressive episode were randomly and equally divided into control group(Paroxetine)and observation group(Paroxetine+Quetiapine).The effective rates of treatment,Hamilton depression scale 17(HAMD-17)scores,depression rating scale(CES-D)scores,inflammatory factors,GQOLI-74 scores,and drug adverse reaction rates between two groups were compared.Results The effective rate of observation group was higher than that of control group(P＜0.05).The HAMD-17 score,CES-D score,tumor necrosis factor alpha(TNF-α),and interleukin-1(IL-1)were lower in the observation group than those in the control group,while IL-10 and GQOLI-74 score were higher in the observation group than those of the control group after 6 weeks of treatment(P＜0.05),and the observation group showed better improvement than the control group(P＜0.05).There was no difference in adverse reactions between the two groups.Conclusion Paroxetine combining Quetiapine can change the levels of TNF-α,IL-1,IL-10 in patients with BPD depression,alleviate depression,and improve quality of life,making it worth promoting.
维普
万方数据