Clinical efficacy of Paroxetine combined with Quetiapine in the treatment of depressive epi-sode of bipolar disorder
Aim To evaluate the clinical efficacy of paroxetine plus quetiapine in patients with bipolar disorder(BPD)de-pressive episodes.Methods 100 patients with BPD depressive episode were randomly and equally divided into control group(Paroxetine)and observation group(Paroxetine+Quetiapine).The effective rates of treatment,Hamilton depression scale 17(HAMD-17)scores,depression rating scale(CES-D)scores,inflammatory factors,GQOLI-74 scores,and drug adverse reaction rates between two groups were compared.Results The effective rate of observation group was higher than that of control group(P＜0.05).The HAMD-17 score,CES-D score,tumor necrosis factor alpha(TNF-α),and interleukin-1(IL-1)were lower in the observation group than those in the control group,while IL-10 and GQOLI-74 score were higher in the observation group than those of the control group after 6 weeks of treatment(P＜0.05),and the observation group showed better improvement than the control group(P＜0.05).There was no difference in adverse reactions between the two groups.Conclusion Paroxetine combining Quetiapine can change the levels of TNF-α,IL-1,IL-10 in patients with BPD depression,alleviate depression,and improve quality of life,making it worth promoting.
万方数据
维普
