The clinical value of thromboelastography combined with hs-CRP and HbA1c levels in pre-dicting progressive ischemic stroke
Aim To explore the predictive value of thromboelastogram combined with hypersensitive C-reactive protein(hs-CRP)and glycosylated hemoglobin(HbA1c)levels for progressive ischemic stroke.Methods Retrospective analysis was con-ducted on 120 patients with acute ischemic stroke admitted,with a progressive group of 37 cases and a non-progressive group of 83 ca-ses,and during the same period,120 healthy individuals underwent physical examinations were used as the control group.General information,hs-CRP,HbA1c levels,and thromboelastography parameters of all study subjects were collected.Logistic multivariate analysis was performed on the occurrence of progressive ischemic stroke,and the predictive value of hs-CRP,HbA1c,and throm-boelastography parameters were analyzed by using ROC.Results The national institute of health stroke scale of the progressive group was higher than that of the non-progressive group(P＜0.05).Compared with the control group,the hs-CRP and HbA1c levels were higher in the progressive group and non-progressive group,and the progressive group was higher than those in the non-progressive group.The reaction time and coagulation time were shorter,and the progressive group was shorter than those in the non-progressive group.The coagulation angle and maximum amplitude were larger,and the progressive group was greater than those in the non-pro-gressive group(P＜0.05).Multivariate Logistic regression analysis found that hs-CRP,HbA1c,coagulation time,coagulation angle,and maximum amplitude were the influencing factors for the progression of acute ischemic stroke patients(P＜0.05).Through ROC curve analysis,it can be concluded that the AUC of hs-CRP,HbA1c,and thromboelastography in predicting the progression of acute ischemic stroke patients is 0.751,0.732,and 0.737,respectively.The combination had the highest predictive efficacy,with sensi-tivity and specificity of 0.703 and 0.916,respectively.Conclusion Hs-CRP,HbA1c and thromboelastogram have high predictive value for the occurrence of progressive ischemic stroke,and the combination of the three has the best overall effect for prediction.
hypersensitive C-reactiveglycosylated hemoglobinthromboelastogramprogressive ischemic strokepredictive value
万方数据
维普
