摘要
目的 探究血栓弹力图联合超敏C反应蛋白(hs-CRP)、糖化血红蛋白(HbA1c)水平对进展性缺血性脑卒中的预测价值.方法 回顾性分析收治的120例急性缺血性脑卒中患者,分为进展组37例和非进展组83例,同期120例健康体检者作为对照组.收集所有研究对象的一般资料、hs-CRP、HbA1c水平和血栓弹力图参数,对其发生进展性缺血性脑卒中进行Logistic多因素分析,采用ROC对其hs-CRP、HbA1c和血栓弹力图参数预测价值进行分析.结果 进展组美国国立卫生研究院卒中量表评分高于非进展组(P＜0.05).与对照组比较,进展组和非进展组hs-CRP、HbA1c水平更高,且进展组高于非进展组,反应时间和凝固时间更短,且进展组短于非进展组,凝固角和最大振幅更大,且进展组大于非进展组(P＜0.05);多因素Lo-gistic 回归性分析发现,hs-CRP、HbA1c、凝固时间、凝固角和最大振幅是急性缺血性脑卒中患者出现进展的影响因素(P＜0.05).ROC分析可得,hs-CRP、HbA1c和血栓弹力图3项指标预测急性缺血性脑卒中患者发生进展的AUC分别为0.751、0.732、0.737,其联合预测效能最高,灵敏度和特异度分别为0.703和0.916.结论 hs-CRP、HbA1c和血栓弹力图对于进展性缺血性脑卒中的发生均有较高的预测价值,三者联合预测的整体效能最佳.
Abstract
Aim To explore the predictive value of thromboelastogram combined with hypersensitive C-reactive protein(hs-CRP)and glycosylated hemoglobin(HbA1c)levels for progressive ischemic stroke.Methods Retrospective analysis was con-ducted on 120 patients with acute ischemic stroke admitted,with a progressive group of 37 cases and a non-progressive group of 83 ca-ses,and during the same period,120 healthy individuals underwent physical examinations were used as the control group.General information,hs-CRP,HbA1c levels,and thromboelastography parameters of all study subjects were collected.Logistic multivariate analysis was performed on the occurrence of progressive ischemic stroke,and the predictive value of hs-CRP,HbA1c,and throm-boelastography parameters were analyzed by using ROC.Results The national institute of health stroke scale of the progressive group was higher than that of the non-progressive group(P＜0.05).Compared with the control group,the hs-CRP and HbA1c levels were higher in the progressive group and non-progressive group,and the progressive group was higher than those in the non-progressive group.The reaction time and coagulation time were shorter,and the progressive group was shorter than those in the non-progressive group.The coagulation angle and maximum amplitude were larger,and the progressive group was greater than those in the non-pro-gressive group(P＜0.05).Multivariate Logistic regression analysis found that hs-CRP,HbA1c,coagulation time,coagulation angle,and maximum amplitude were the influencing factors for the progression of acute ischemic stroke patients(P＜0.05).Through ROC curve analysis,it can be concluded that the AUC of hs-CRP,HbA1c,and thromboelastography in predicting the progression of acute ischemic stroke patients is 0.751,0.732,and 0.737,respectively.The combination had the highest predictive efficacy,with sensi-tivity and specificity of 0.703 and 0.916,respectively.Conclusion Hs-CRP,HbA1c and thromboelastogram have high predictive value for the occurrence of progressive ischemic stroke,and the combination of the three has the best overall effect for prediction.
基金项目
佛山市自筹经费类科技创新项目(2220001004029)
维普
万方数据