Relationship between CT features of elderly lung cancer patients with pulmonary invasive fungal infection and the expression of CLRs in PBMCs
Aim To investigate the relationship between CT features of elderly lung cancer patients with pulmonary invasive fungal infection and the expression of C-type lectin receptors(CLRs)in peripheral blood mononuclear cells(PBMCs).Methods One hundred elderly lung cancer patients were divided into infection group and non-infection group based on the presence or absence of invasive fungal infection in the lungs.CT features and expression of CLRs in PBMCs of the two groups were compared.COX regres-sion analysis was performed to screen the influencing factors of infection.The relationship between CT features and the expression of CLRs in PBMCs was clarified.Results Compared with the non-infection group,the proportions of patients ≥80 years old,using glucocorticoids,time of using antibiotics＞14 days,invasive procedures and CT imaging classification as diffuse type were increased in the infection group,while the proportion of CT classification as nodular type and the expression level of CLRs were decreased signifi-cantly(P＜0.05).COX regression analysis indicated that age,use of glucocorticoids,time of using antibiotics,invasive procedures,and expression of CLRs were influencing factors of infection(P＜0.05).The expression levels of CLRs in patients with diffuse type were significantly lower than those in patients with other types in the infection group(P＜0.05).Conclusion CT features of eld-erly lung cancer patients with pulmonary invasive fungal infection are related to the expression of CLRs in PBMCs.Strictly controlling the use of antibiotics and hormones and reducing invasive procedures plays a positive role in reducing the risk of pulmonary invasive fungal infection.
万方数据
维普
