Association between the expression of miR-21,miR-146a and miR-224 in lesion tissues of pa-tients with cervical lesions and HR-HPV infection and the degree of cervical lesions
Aim To analyze the association between the expression of miR-21,miR-146a and miR-224 in lesion tissues of patients with cervical lesions and high risk-human papilloma virus(HR-HPV)infection and the degree of cervical lesions.Meth-ods According to the degree of cervical lesions,252 patients were divided into the cervical cancer group,the low-grade squamous in-traepithelial lesion(LSIL)group and the high-grade squamous intraepithelial lesion(HSIL)group.According to the presence or ab-sence of HR-HPV infection,the patients were divided into infection group and non-infection group.Meanwhile,84 patients with nor-mal cervix and uterine fibroids were selected as the control group.PCR method was used to detect the expression levels of miR-21,miR-146a and miR-224 in each group.The relationship between clinicopathological characteristics of cervical cancer patients and the expression of miR-21,miR-146a and miR-224 was analyzed.Results miR-224 level in the infection group and the non-infection group was higher than that in the control group,and miR-224 level in the infection group was higher than that in the non-infection group.miR-224 level in the cervical cancer group was higher than those in the control group,LSIL group and HSIL group(P＜0.05).The expression of miR-224 in lesion tissues of cervical cancer patients with low differentiation,patients at FIGO stage Ⅱb-Ⅲa and patients with lymph node metastasis was higher than that in patients with moderate and high differentiation,patients at FIGO stage Ⅰb-Ⅱa,patients without lymph node metastasis and patients without HR-HPV infection(P＜0.05).Differentiation degree,HR-HPV infection,FIGO staging and lymph node metastasis were factors affecting miR-224 level in lesion tissues of patients with cer-vical lesions.Conclusion The expression of miR-224 is significantly up-regulated in cervical cancer tissues,and cervical cancer patients with HR-HPV infection have higher miR-224 levels.HR-HPV infection,differentiation degree,FIGO staging and lymph node metastasis are closely related to the expression of miR-224 in cervical cancer tissues.
万方数据
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