Predictive efficacy of DWI with different b-values on postoperative Gleason scores in prostate cancer patients
Aim To evaluate the clinical value of diffusion weighted imaging(DWI)magnetic resonance imaging(MRI)with different b-values in predicting postoperative Gleason scores in prostate cancer patients.Methods Sixty-two prostate cancer patients who accepted puncture biopsy and radical prostatectomy were selected and divided into low-grade group(＜7 points,n=39)and intermediate-to-high-grade group(≥7 points,n=23)based on the postoperative Gleason scores.ROC was plotted to evaluate the predictive efficacy of different b values on postoperative Gleason scores in patients with prostate cancer.Results The prostate volume in intermediate-to-high-grade group was smaller than that in low-grade group(P＜0.05).The lesions of the patients showed as hyperintense signal on DWI,while the apparent diffusion coefficient(ADC)for different b-values were all smaller in intermediate-to-high-grade group than in low grade group(P＜0.05).The AUC of ADCb50,ADCb400 and ADCb800 for predicting postoperative Gl-eason scores in prostate cancer patients were 0.690,0.703,and 0.775,respectively.All of them had certain predictive efficacy for postoperative Gleason scores≥7 in prostate cancer patients,while the b value of 800 s/mm2 provided the highest predictive specificity and sensitivity,reaching 87.2％and 60.9％,respectively.Conclusion MRI is of certain value in predicting the postoperative Gleason score≥7 in prostate cancer patients,with the highest specificity and sensitivity at a b-value of 800 s/mm2.
magnetic resonance imagingprostate cancerGleason scoreapparent diffusion coefficientdiffusion weighted imaging
万方数据
维普
