Post-craniotomy intracranial infection is a serious complication in neurosurgery,with high rates of disability and mor-tality.The specificity and sensitivity of routine clinical detection of intracranial infection indicators were insufficient,and cerebrospi-nal fluid bacterial culture was time-consuming and had a low positive rate.In recent years,heparin binding protein(HBP),serum amyloid A(SAA),and neutrophil CD64 have unique advantages in sensitivity and specificity as novel infection markers,and their de-tection methods were simple and fast.They have broad clinical application prospects in infection diagnosis,efficacy evaluation,prog-nosis judgment,and other aspects.This article reviews the diagnostic value,clinical application,and detection methods of HBP,SAA,and nCD64 in the early stage of intracranial infection.
关键词
肝素结合蛋白/血清淀粉样蛋白A/中性粒细胞CD64/颅内感染/早期诊疗
Key words
HBP/SAA/nCD64/intracranial infection/early diagnosis and treatment
维普
万方数据