Effects of vitamin D derivative Calciportriol on therapeutic efficacy and related inflammatory factors in mice with alopecia areata
Aim To investigate the efficacy of Calciportriol,a vitamin D derivative,on mice with alopecia areata and related inflammatory factors.Methods Mouse models of alopecia areata were constructed.Then,the vitamin D derivative calcipotriol was evenly smeared on the alopecia areata area of the mice.The efficacy of alopecia areata in the mice was observed.Furthermore,immunofluorescence staining was used to detect CD4+,CD8+T cells and related cytokines,such as TNF-α and IL-6,in alopecia areata areas.Results Alopecia areata disappeared completely after treatment with Calciportriol,and the effective rate was 100％.The number of CD4+and CD8+T cells associated with inflammation around mouse hair follicle cells decreased,accompanying with sup-pressed secretion of inflammatory cytokines such as TNF-α and IL-6(P＜0.05).Conclusion Carpotriol can significantly improve alopecia areata in mice by inhibiting the number of CD4+and CD8+T cells and the secretion of TNF-α,IL-6 and other inflammatory cy-tokines around hair follicle cells.
vitamin D derivativecalciportriolvitamin D receptoralopecia areatainflammatory factors
万方数据
维普
