Efficacy of trazodone combined with fluvoxamine on the treatment of depression with insomnia and the effects on polysomnography and serum levels of peptide neurotransmitters and IL-1β
Aim To observe the clinical efficacy of trazodone combined with fluvoxamine on the treatment of depression with insomnia and the effects on polysomnogram,serum peptide neurotransmitter,interleukin(IL)-1 β levels.Methods 360 patients with depression accompanied by insomnia were selected and divided into control group(fluvoxamine maleate treatment)and observation group(trazodone hydrochloride combined with fluvoxamine maleate treatment)according to different treatment methods.17 items of Hamilton depression scale(HAMD-17),Pittsburgh sleep quality index(PSQI),36-item short form health survey(SF-36)scores,polysomnography parameters,serum neuropeptide Y(NPY),substance P(SP)and IL-1β levels were compared between the two groups before and after treatment.The clinical efficacy and adverse reactions were compared between the two groups.Results Compared with parameters before treatment,the total score of HAMD-17,PSQI,SP,IL-1β levels were decreased after treatment(P＜0.05),while the total score of SF-36 and serum NPY levels were increased(P＜0.05).Total sleep time,rapid eye movement-sleep time and slow-wave sleep time were significantly extended(P＜0.05),wake times was decreased(P＜0.05),sleep efficiency was in-creased(P＜0.05),and sleep latency and wake time were shortened(P＜0.05).The improvement was more significant in the obser-vation group(P＜0.05).The total effective rate of observation group was higher than that of control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Trazodone com-bined with fluvoxamine can significantly improve the depressive symptoms,sleep process and structure of patients with depression and insomnia symptoms,effectively improve the overall treatment effect,and can regulate the levels of serum related peptide neurotransmit-ters and IL-1β in a benign manner,with good patient tolerance.
万方数据
维普
