Analysis of influencing factors on the severity of pulmonary heart disease and pulmonary ar-terial hypertension in patients
Aim To analyze the influencing factors of the severity of pulmonary heart disease and pulmonary arterial hyper-tension in patients.Methods 219 patients with pulmonary heart disease and pulmonary arterial hypertension were selected and divided into WHO-FC grade Ⅱ,Ⅲ,and Ⅳ groups,respectively,according to the severity of their condition.The levels of serum B-type brain natriuretic peptide(BNP),high mobility histone B1(HMGB1),interleukin-18(IL-18),lung function[forced vital ca-pacity(FVC),the forced expiratory volume in one second/predicted value ratio(FEV1％pred),FEV1/FVC],heart function and he-modynamic indicators[pulmonary capillary wedge pressure(PCWP),pulmonary vascular resistance(PVR),cardiac index(CI)]a-mong different groups were compared.The correlation between various indicators and possible factors affecting the survival of patients with pulmonary heart disease and pulmonary arterial hypertension was analyzed.Results As the patient's cardiac function grading increases,the levels of serum BNP,HGMB1,and IL-18 increase,while FEV1％pred,FEV1/FVC,PCWP,and CI decrease(P＜0.05).The levels of serum BNP,HGMB1,IL-18 were negatively correlated with FEV1％pred,FEV1/FVC,PCWP,and CI(P＜0.05).BNP,HGMB1,and IL-18 were influencing factors on the severity and prognosis of pulmonary heart disease and pulmonary arterial hypertension patients(P＜0.05).Conclusion Serum BNP,HGMB1,and IL-18 are independent influencing factors on the severity and prognosis of pulmonary heart disease and pulmonary arterial hypertension patients.
万方数据
维普
