Observation of EGFR gene mutations,tumor marker levels in pleural effusion,and prognosis of NSCLC
Aim To observe the detection rate of epidermal growth factor receptor(EGFR)gene mutations,tumor marker levels in pleural effusion,and prognosis of non-small cell lung cancer(NSCLC)patients.Methods 117 patients with advanced NSCLC complicated with pleural effusion who received treatment in our hospital were selected as the research subjects.The patients were divided into EGFR mutant group(mutant group)and non-mutant group(wild-type group)according to the EGFR gene mutation detection results of the pleural effusion before treatment.Patients in the mutant group received tyrosine kinase inhibitor(TKI)treat-ment,while patients in the wild-type group received conventional chemotherapy.The levels of tumor markers,clinical and pathologi-cal characteristics,short-term efficacy,and prognosis outcomes in two groups were compared.Results Among 117 NSCLC pa-tients,47 patients developed EGFR mutations,with a mutation rate of 40.17％.Compared with the wild-type group,the serum carcino-embryonic antigen(CEA)level and the proportion of adenocarcinoma and TNM stage Ⅳ were increased in the mutant group(P＜0.05),and the levels of carbohydrate antigen 125(CA125),squamous cell carcinoma antigen(SCCA),cytokeratin 19 fragment(CYFRA21-1),the proportion of smoking and low differentiation were decreased in the mutant group(P＜0.05).The overall thera-peutic effect of mutant group was better than that of wild-type group(P＜0.05).The survival rate of patients in the mutant group was higher than that in the wild-type group(P＜0.05).The median survival time of the mutant group was longer than that of the wild-type group(P＜0.05).Conclusion The serum CEA levels of EGFR mutant NSCLC patients are higher than those of wild-type pa-tients,while CA125,SCCA,and CYFRA21-1 levels are lower than those of wild-type patients.At the same time,the short-term effi-cacy and prognosis of TKI treatment in mutant patients are better than those in wild-type patients receiving conventional chemotherapy.
万方数据
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