The clinical value of real-time shear wave elastography in quantitative evaluation of bile acid stasis syndrome in pregnant women
Aim To explore the clinical value of real-time shear wave elastography(SWE)in quantitative assessment of cholestasis syndrome(CS)in pregnant women.Methods 121 cases of pregnant women with CS(CS group)and 115 cases of normal pregnant women(control group)were selected.General data,bile acids,alanine aminotransferase,aspartate aminotrans-ferase,total bilirubin,and direct bilirubin,in the two groups were compared;ROC curve was used to analyze the diagnostic efficacy of SWE on choleacidosis syndrome in pregnant women.Results The gestational age,liver elasticity value,bile acids,alanine ami-notransferase,aspartate aminotransferase,total bilirubin,and direct bilirubin in CS group were significantly higher than control group(P＜0.05).After controlling the age,gestational period,glutamate aminotransferase,aspartate aminotransferase,total bilirubin and direct bilirubin,the risk of CS increased 7.966 times with every 1 unit increase in liver elasticity.The area under the ROC curve for liver elasticity value diagnosis of CS is 0.910(0.873,0.946).The optimal cut-off point is liver elasticity value greater than 6.44.At this time,the sensitivity and specificity are 75.7％and 96.7％respectively,and the Youden index is 0.724.Conclusion Real-time shear wave elastography can accurately and non-invasively assess the liver condition of pregnant women with cholestasis syn-drome at an early stage,and has high clinical value for early diagnosis,treatment and intervention of CS.
万方数据
维普
