Analysis of risk factors and predictors of hypertensive disorders in pregnant women with PCOS
Aim To screen the risk factors and predictive indicators of hypertensive disorders of pregnancy(HDP)in preg-nant women with polycystic ovary syndrome(PCOS).Methods The clinical data of 217 hospitalized PCOS pregnant women in our hospital were selected,and divided into HDP group and non-HDP group based on whether HDP occurs after 20 weeks of pregnancy.The clinical datas between HDP group and non-HDP group were compared.Influencing factors of PCOS pregnant women with HDP were analyzed by using Logistic multiple regression.The predictor of HDP in pregnant women with PCOS was evaluated by using ROC analysis.Results Among 217 pregnant women with PCOS,41(18.89％)developed HDP.The proportion of HDP family history,long-term passive smoking history,pre-pregnancy body mass index(BMI),and homeostasis model assessment of insulin re-sistance(HOMA-IR)in the HDP group were higher than those in the non-HDP group.The levels of sex hormone binding globulin(SHBG),placental growth factor(PlGF),and pregnancy-associated plasma protein-A(PAPP-A)in early pregnancy were lower than those in the non-HDP group(P＜0.05).Pre-pregnancy BMI and early pregnancy HOMA-IR were risk factors for HDP in PCOS pregnant women,while early pregnancy serum SHBG and PIGF were protective factors(P＜0.05).The sensitivity of early pregnancy serum PlGF in predicting HDP in PCOS pregnant women was the highest,while the specificity of pre-pregnancy BMI prediction was the highest.Conclusion Pre-pregnancy BMI,early pregnancy blood SHBG,PlGF,and HOMA-IR are the influencing factors for the occurrence of HDP in PCOS pregnant women,with pre-pregnancy BMI and PlGF serving as predictive indicators.
PCOShypertensive disorders of pregnancyrisk factorspredictor
万方数据
维普
