The relationship between plasma coagulation function indicators and delayed cerebral hemor-rhage secondary to traumatic brain injury
Aim To investigate the relationship between plasma D-dimer(D-D),fibrinogen(Fg),and activated coagulation factor Ⅶ(FVlla),and delayed cerebral hemorrhage secondary to traumatic brain injury in terms of coagulation function.Methods 88 patients with delayed cerebral hemorrhage secondary to traumatic brain injury were selected as the observation group,and 210 patients without cerebral hemorrhage due to traumatic brain injury were selected as the control group.The clinical data of the two groups were compared,and plasma D-D,Fg,FⅦa,prothrombin time(PT),as well as activated partial thromboplastin time(APTT),were detected.The diagnostic efficacy of coagulation function indicators for delayed cerebral hemorrhage and the influen-cing factors for delayed cerebral hemorrhage were analyzed.Results The age and GCS score of patients in the observation group were higher than those in the control group(P＜0.05);The observation group had higher levels of D-D,Fg,FⅦa,PT,and APTT than the control group(P＜0.05);The D-D,Fg,FⅦa,PT,and APTT of patients with severe neurological impairment in the observa-tion group were higher than those of patients with mild and moderate impairment(P＜0.05);ROC analysis found that D-D,Fg,FⅦa,PT,and APTT have good diagnostic efficacy for delayed cerebral hemorrhage.The results of logistic regression analysis showed that age,GCS score,D-D,Fg,and FⅦa were the influencing factors for delayed cerebral hemorrhage secondary to traumatic brain injury(P＜0.05).Conclusion Plasma D-D,Fg,and FⅦa are influencing factors for secondary delayed cerebral hemorrhage in pa-tients with traumatic brain injury,and further research is warranted.
万方数据
维普
