The research progress of treating diabetic nephropathy with traditional Chinese medicine based on TGF-β1/Smad signaling pathway
Diabetic nephropathy(DN)is one of the most serious complications of diabetes mellitus(DM),and its occurrence and progress are closely related to renal fibrosis.Therefore,it is of great significance to treat renal fibrosis to delay the progress of DN.Transforming growth factor-β1(TGF-β1),a key factor in renal fibrosis,has been proved to be highly expressed in DN,and is related to almost all cytokines and signal pathways in the progress of DN.Smad is the main target in the middle and lower reaches of TGF-β1 signaling pathway,which forms a classical signaling pathway with TGF-β1 and plays an important role in the progress of renal fibrosis.In recent years,the effect of treating DN by regulating TGF-β1/Smad signaling pathway is ideal,and the research on trea-ting DN by traditional Chinese medicine is gradually increasing.Therefore,this paper reviews the research progress of TGF-β1/Smad signaling pathway in DN,as well as the intervention effect of traditional Chinese medicine on this disease by regulating TGF-β1/Smad signaling pathway and related mechanisms,in order to provide new ideas for clinical guidance and treatment of DN.
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