Efficient mechanical plant protection has become an important means of agricultural production at the present stage.In view of the characteristics of agricultural plant protection technology and agricultural product safety at the pres-ent stage,we analyzed the current situation of plant protection machinery technology and the problems and deficiencies that existed,introduced the relationship between plant protection machinery technology and food safety,as well as the characteristics of the application technology of plant protection machinery based on food safety.From the perspective of agronomic optimization,the introduction of low-residue pesticides,the rational application of green prevention and con-trol technology,and the strengthening of agricultural product testing and other agronomic development proposals are put forward in the hope of providing references for the rational use of plant protection machinery technology and the optimiza-tion of agronomic technology,as well as assisting in the sustainable development of agricultural production.