Effect of the COVID-19 on detrusor contractility in patients with benign prostatic hyperplasia
Objective:The effect of coronavirus disease-2019(COVID-19)on detrusor contractility in patients with benign prostatic hyperplasia(BPH)was investigated using sonography video urodynamics studies(SVUDS).Methods:The clinical dataset,including general condition,inflammatory indexes,and SVUDS parameters of 124 BPH patients with or without COVID-19 infection admitted to the Second Affiliated Hospital of Guilin Medical University and Shaoyang Central Hospital between January and June 2023 were retrospectively reviewed.Those patients were divided into the COVID-19(+)(n=51)and COVID-19(-)(n=73)groups according to the results of virus nucleic acid detection,and the differences in general corditions,inflammatory indicators,and SVUDS parameters were compared between two groups.The correlations of inflammatory indexes and non-invasive SVUDS parameters with detrusor contractility in BPH patients of the COVID-19(+)group were analyzed.Results:The serum level of C-reactive protein(CRP)and interleukin(IL)-6 of BPH patients in the COVID-19(+)group were significantly higher than that of the COVID-19(-)group(P＜0.05),whereas no significant differences in age,IL-1β,prostate specific antigen(PSA),free prostate-specific antigen(fPSA),fPSA/PSA,prostate volume(PV),prostate specific antigen density(PSAD),intravesical prostatic protrusion(IPP),peak flow rate(Qmax),urethral resistance factor(URA),bladder outlet obstruction index(BOOI),footpoint,and curvature were found between the two groups(P＞0.05).Significant thicker bladder wall thickness(BWT),larger post-void residual volume(PVR),and lower value of detrusor contractility indexes,including maximum detrusor pressure(Pdet.max),detrusor pressure at peak flow rate(Pdet.Qmax),bladder contractility index(BCI)and maximum Watts factor(WFmax),were observed in BPH patients of the COVID(+)group,compared with those of the COVTD(-)group(P＜0.05).The negative correlations between BWT and WFmax(r=-0.313,P=0.036),between PVR and BCI(r=-0.471,P=0.001),and between PVR and WFmax(r=-0.491,P=0.001)were found in BPH patients of the COVID-19(+)group.Conclusion:COVID-19 may aggravate detrusor underactivity in BPH patients,resulting to the increased PVR even urinary retention,which may be one urodynamics features of long-COVID in those BPH patients.
COVID-19benign prostatic hyperplasiasonography video urodynamics studiesdetrusor functionlower urinary tract symptoms
万方数据
维普
