南京医科大学学报(自然科学版)2025，Vol.45Issue(1) ：22-28.DOI:10.7655/NYDXBNSN240716

COVID-19对前列腺增生患者逼尿肌收缩功能的影响

Effect of the COVID-19 on detrusor contractility in patients with benign prostatic hyperplasia

肖宁 肖锦华 黄海 唐琦 陈丹 黄秋夏 赵划晟 王建峰
南京医科大学学报(自然科学版)2025，Vol.45Issue(1) ：22-28.DOI:10.7655/NYDXBNSN240716
✕
  • 维普
  • 万方数据

COVID-19对前列腺增生患者逼尿肌收缩功能的影响

Effect of the COVID-19 on detrusor contractility in patients with benign prostatic hyperplasia

肖宁 1肖锦华 2黄海 3唐琦 2陈丹 2黄秋夏 2赵划晟 4王建峰4
扫码查看

作者信息

  • 1. 桂林医学院第二附属医院泌尿外科,广西 桂林 541001;邵阳市中心医院泌尿外科尿控学研究室,湖南 邵阳 422600
  • 2. 桂林医学院第二附属医院泌尿外科,广西 桂林 541001
  • 3. 中山大学孙逸仙纪念医院泌尿外科,广东 广州 510120
  • 4. 邵阳市中心医院泌尿外科尿控学研究室,湖南 邵阳 422600
  • 折叠

摘要

目的:采用超声影像尿动力学检查(sonography video urodynamics studies,SVUDS)分析新型冠状病毒肺炎(coronavi-rus disease-2019,COVID-19)对前列腺增生(benign prostatic hyperplasia,BPH)患者逼尿肌收缩功能的影响.方法:纳入桂林医学院第二附属医院及邵阳市中心医院2023年1-6月诊断为BPH伴或不伴COVID-19感染患者124例进行回顾性研究分析.根据病毒核酸检测阳性或阴性情况分为COVID-19(+)组51例和COVID-19(-)组73例.比较两组患者一般情况、炎症指标及SVUDS参数差异,分析COVID-19(+)组患者炎症指标及无创性SVUDS参数与逼尿肌收缩功能的相关性.结果:COVID-19(+)组患者C反应蛋白(C-reactive protein,CRP)、白介素(interleukin,IL)-6高于COVID-19(-)组患者(P＜0.05).两组患者年龄、IL-1β、前列腺特异性抗原(prostate specific antigen,PSA)、游离前列腺特异性抗原(free prostate-specific antigen,fPSA)、fPSA/PSA、前列腺体积(prostate volume,PV)、前列腺特异性抗原密度(prostate specific antigen density,PSAD)、前列腺突入膀胱距离(intra-vesical prostatic protrusion,IPP)、最大尿流率(peak flow rate,Qmax)、尿道阻力因子(urethral resistance factor,URA)、膀胱出口梗阻指数(bladder outlet obstruction index,BOOI)、基点(footpoint)、曲率(curvature)差异无统计学意义(P＞0.05).相比 COVID-19(-)组,COVID-19(+)组最大逼尿肌压(maximum detrusor pressure,Pdet.max)、最大尿流率逼尿肌压(detrusor pressure at peak flow rate,Pdet.Qmax)、膀胱收缩指数(bladder contractility index,BCI)和最大瓦特因子(maximum Watts factor,WFmax)降低,膀胱壁厚度(bladder wall thickness,BWT)和残余尿量(post-void residual volume,PVR)增加(P 均＜0.05).COVID-19(+)组患者BWT 与 WFmax 呈负相关(r=-0.313,P=0.036),PVR 与 BCI(r=-0.471,P=0.001)和 WFmax(r=-0.491,P=0.001)均呈负相关.结论:BPH患者若合并COVID-19感染可能进一步加重逼尿肌活动低下,导致残余尿量增加甚至尿潴留,逼尿肌活动低下可能是BPH患者"long-COVID"尿动力学表现之一.

Abstract

Objective:The effect of coronavirus disease-2019(COVID-19)on detrusor contractility in patients with benign prostatic hyperplasia(BPH)was investigated using sonography video urodynamics studies(SVUDS).Methods:The clinical dataset,including general condition,inflammatory indexes,and SVUDS parameters of 124 BPH patients with or without COVID-19 infection admitted to the Second Affiliated Hospital of Guilin Medical University and Shaoyang Central Hospital between January and June 2023 were retrospectively reviewed.Those patients were divided into the COVID-19(+)(n=51)and COVID-19(-)(n=73)groups according to the results of virus nucleic acid detection,and the differences in general corditions,inflammatory indicators,and SVUDS parameters were compared between two groups.The correlations of inflammatory indexes and non-invasive SVUDS parameters with detrusor contractility in BPH patients of the COVID-19(+)group were analyzed.Results:The serum level of C-reactive protein(CRP)and interleukin(IL)-6 of BPH patients in the COVID-19(+)group were significantly higher than that of the COVID-19(-)group(P＜0.05),whereas no significant differences in age,IL-1β,prostate specific antigen(PSA),free prostate-specific antigen(fPSA),fPSA/PSA,prostate volume(PV),prostate specific antigen density(PSAD),intravesical prostatic protrusion(IPP),peak flow rate(Qmax),urethral resistance factor(URA),bladder outlet obstruction index(BOOI),footpoint,and curvature were found between the two groups(P＞0.05).Significant thicker bladder wall thickness(BWT),larger post-void residual volume(PVR),and lower value of detrusor contractility indexes,including maximum detrusor pressure(Pdet.max),detrusor pressure at peak flow rate(Pdet.Qmax),bladder contractility index(BCI)and maximum Watts factor(WFmax),were observed in BPH patients of the COVID(+)group,compared with those of the COVTD(-)group(P＜0.05).The negative correlations between BWT and WFmax(r=-0.313,P=0.036),between PVR and BCI(r=-0.471,P=0.001),and between PVR and WFmax(r=-0.491,P=0.001)were found in BPH patients of the COVID-19(+)group.Conclusion:COVID-19 may aggravate detrusor underactivity in BPH patients,resulting to the increased PVR even urinary retention,which may be one urodynamics features of long-COVID in those BPH patients.

关键词

COVID-19/前列腺增生/超声影像尿动力学/逼尿肌功能/下尿路症状

Key words

COVID-19/benign prostatic hyperplasia/sonography video urodynamics studies/detrusor function/lower urinary tract symptoms

引用本文复制引用

出版年

2025
南京医科大学学报(自然科学版)
南京医科大学

南京医科大学学报(自然科学版)

北大核心
影响因子：0.646
ISSN：1007-4368
段落导航相关论文