前列腺癌是全球男性最常见的恶性肿瘤之一,严重危害男性身体健康.自前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)被证实是诊断前列腺癌的首选标志物,PSMA靶向放射性药物在前列腺癌诊治中取得显著进展,有效提高了前列腺癌的诊断灵敏度与治疗效果.文章就近年来PSMA靶向放射性分子探针的相关研究进展进行综述,分析探针结构设计理念并总结临床经验,以期对前列腺癌放射性诊疗分子探针的开发有所裨益.
Research progress of PSMA-targeted radioactive small molecular probes for the diagnosis and treatment of prostate cancer
Prostate cancer is one of the most common malignant tumors among men worldwide,posing a significant threat to male health.Since prostate-specific membrane antigen(PSMA)has been proved to be the preferred biomarker for the diagnosis of prostate cancer,PSMA-targeted radiopharmaceuticals have made significant progress in the diagnosis and therapy of prostate cancer,effectively improving the diagnostic sensitivity and treatment effect of prostate cancer.This article reviews the research progress of PSMA-targeted radioactive molecular probes in recent years,analyzes the design concepts of probe structure and summarizes the clinical experience.It is expected to benefit the development of radioactive molecular probes for diagnosis and treatment of prostate cancer.
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