Predictive value of acute gastrointestinal injury grade combined with SOFA score in 28-day prognosis in patients with sepsis
Objective:To evaluate the predictive value of the acute gastrointestinal injury(AGI)grade and the sequen-tial organ failure assessment(SOFA)score in the 28-day prognosis of patients with sepsis.Methods:A total of 192 patients with sepsis admitted to emergency intensive care unit(EICU)were selected as the study objects.They were divided into survival group and death group according to 28-day survival,and the clinical characteristics of the two groups were com-pared.The AGI grade was recorded daily within one week after admission,and the clinical characteristics of patients with different AGI grades were analyzed.The receiver operating characteristic(ROC)curves of AGI grade,SOFA score,the acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)score and AGI grade combined with SOFA score on the 28-day prognosis of patients were drawn respectively,and the corresponding area under curve(AUC)was calculated and compared.Results:Totally,192 patients with sepsis were included.The 28-day mortality was 38.0％(73/192),and the incidence of AGI was 89.1％(171/192).There were 69 patients with grade 1,72 patients with grade 2,26 patients with grade 3 and 4 patients with grade 4.With the increase of AGI grade,the critical illness scores increased,and the 28-day mortality increased significantly.Multiple regression analysis showed that age,lactic acid,mechanical ventilation(MV),AGI grade and APACHE Ⅱ score were independent risk factors for 28-day mortality in patients with sepsis.The ROC curve analysis showed that the predictive ability of AGI grade or SOFA score on 28-day mortality was lower than APACHE Ⅱ score,but their combined predictive ability was not significantly different from APACHE Ⅱ score.Conclusion:AGI is common in patients with sepsis in emergency department.The predictive ability of AGI grade combined with SOFA score on 28-day mor-tality is valuable in patients with sepsis.
Acute gastrointestinal injurySequential organ failure assessmentSepsisAdverse prognosis
NETL
NSTL
万方数据
