Helicobacter pylori infection has no effect on liver inflammation and liver fibrosis in patients with nonalcoholic fatty liver disease
Objective:To explore the relationship between Helicobacter pylori(HP)infection and nonalcoholic fatty liv-er disease,and the relationship between Helicobacter pylori infection and the degree of inflammation and fibrosis in patients with nonalcoholic fatty liver disease.Methods:A retrospective cross-sectional study was conducted on 3133 physical exami-nation people,who were divided into NAFLD group and control group.The metabolic related indexes and the proportion of HP infection in the two groups were compared and analyzed.The NAFLD group was divided into HP positive group and HP negative group.The indexes of liver inflammation and liver fibrosis were compared and analyzed between the two groups.Results:Multivariate Logistic regression analysis showed that increased body mass index(BMI)(OR=1.366,95％CI:1.314-1.420,P＜0.001),abnormal glucose metabolism(OR=2.066,95％CI:1.628-2.621,P＜0.001),increased triglycerides(TG)(OR=2.298,95％CI:1.928-2.739,P＜0.001),increased low-density lipoprotein(LDL)(OR=2.147,95％CI:1.535-3.005,P＜0.001),and elevated uric acid(OR=1.003,95％CI:1.002-1.005,P＜0.001)were independent risk factor for NAFLD.HP infection was not an independent risk factor for NAFLD(OR=1.146,95％CI:0.935-1.404,P=0.188).In NAFLD group,there were no significant differences in liver inflammation related indexes(γ-GT,ALT,AST)and liver fibrosis indexes(FIB-4,NFS)between HP positive group and HP negative group(P＞0.05).Conclusion:Increased BMI,abnormal glucose metabolism,increased TG,increased LDL and elevated uric acid are independent risk factors for NAFLD.HP infection is not an independent risk factor for NAFLD.HP infection has no effect on liver inflammation and liver fibrosis in patients with NAFLD.
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