幽门螺杆菌感染对非酒精性脂肪性肝病患者肝脏炎症及纤维化无影响
Helicobacter pylori infection has no effect on liver inflammation and liver fibrosis in patients with nonalcoholic fatty liver disease
易维 1饶才俊 1王金丽 1高翔 1凃玲 1黄骁燕1
作者信息
- 1. 华中科技大学同济医学院附属同济医院综合医疗科,湖北武汉 430030
- 折叠
摘要
目的:研究幽门螺杆菌(HP)感染与非酒精性脂肪性肝病(NAFLD)发生发展的相关性及HP感染与NAFLD患者肝脏炎症与纤维化程度的关系.方法:纳入3 133例体检人群进行回顾性横断面研究,分为NAFLD组及对照组,比较2组代谢相关指标及HP感染比例;将NAFLD组分为HP阳性组和HP阴性组,比较2组患者肝脏炎症和纤维化指标.结果:多因素Logistic回归分析显示,体质指数(BMI)增加(OR=1.366,95％CI:1.314～1.420,P＜0.001)、糖代谢异常(OR=2.066,95％CI:1.628～2.621,P＜0.001)、甘油三酯(TG)升高(OR=2.298,95％CI:1.928～2.739,P＜0.001)、低密度脂蛋白(LDL)升高(OR=2.147,95％CI:1.535～3.005,P＜0.001)、尿酸升高(OR=1.003,95％CI:1.002～1.005,P＜0.001)是NAFLD的独立危险因素,HP感染不是NAFLD的独立危险因素(OR=1.146,95％CI:0.935～1.404,P=0.188).NAFLD患者中,HP阳性与HP阴性患者比较,肝脏炎症相关指标及肝脏纤维化指标差异均无统计学意义(P均＞0.05).结论:BMI增加、糖代谢异常、TG升高、LDL升高、尿酸升高是NAFLD的独立危险因素,HP感染不是NAFLD的独立危险因素,HP感染对NAFLD患者肝脏炎症及肝纤维化无影响.
Abstract
Objective:To explore the relationship between Helicobacter pylori(HP)infection and nonalcoholic fatty liv-er disease,and the relationship between Helicobacter pylori infection and the degree of inflammation and fibrosis in patients with nonalcoholic fatty liver disease.Methods:A retrospective cross-sectional study was conducted on 3133 physical exami-nation people,who were divided into NAFLD group and control group.The metabolic related indexes and the proportion of HP infection in the two groups were compared and analyzed.The NAFLD group was divided into HP positive group and HP negative group.The indexes of liver inflammation and liver fibrosis were compared and analyzed between the two groups.Results:Multivariate Logistic regression analysis showed that increased body mass index(BMI)(OR=1.366,95％CI:1.314-1.420,P＜0.001),abnormal glucose metabolism(OR=2.066,95％CI:1.628-2.621,P＜0.001),increased triglycerides(TG)(OR=2.298,95％CI:1.928-2.739,P＜0.001),increased low-density lipoprotein(LDL)(OR=2.147,95％CI:1.535-3.005,P＜0.001),and elevated uric acid(OR=1.003,95％CI:1.002-1.005,P＜0.001)were independent risk factor for NAFLD.HP infection was not an independent risk factor for NAFLD(OR=1.146,95％CI:0.935-1.404,P=0.188).In NAFLD group,there were no significant differences in liver inflammation related indexes(γ-GT,ALT,AST)and liver fibrosis indexes(FIB-4,NFS)between HP positive group and HP negative group(P＞0.05).Conclusion:Increased BMI,abnormal glucose metabolism,increased TG,increased LDL and elevated uric acid are independent risk factors for NAFLD.HP infection is not an independent risk factor for NAFLD.HP infection has no effect on liver inflammation and liver fibrosis in patients with NAFLD.
关键词
幽门螺杆菌感染/非酒精性脂肪性肝病/危险因素/肝脏炎症/肝脏纤维化Key words
Helicobacter pylori infection/Nonalcoholic fatty liver disease/Risk factors/Liver inflammation/Hepatic fibrosis引用本文复制引用
基金项目
湖北省自然科学基金(2021CFB339)
出版年
2024
NETL
NSTL
万方数据