Relationship between serum procalcitonin and platelet parameters in patients with sepsis and its value in prognosis
Objective:To investigate the correlation between platelet parameters and procalcitonin(PCT)levels in patients with sepsis and common infection and their significance in the prognosis evaluation of sepsis.Methods:A total of 192 patients were collected for retrospective analysis,and platelet parameters were compared between the two groups:platelet count,thrombocytocrit,mean platelet volume(MPV),platelet distribution width(PDW)and platelet large cell ratio(P-LCR)and PCT,and the impact of PCT levels and platelet parameters on sepsis prognosis was analyzed.Results:As com-pared with the common infection group,MPV,PDW,P-LCR and PCT in the sepsis group were significantly increased.When PCT was greater than 5.0 ng/mL,the number of platelets in the sepsis patients was significantly decreased.MPV,PDW and PLR were significantly higher in the sepsis group than those in the common infection group.When PCT was less than 0.5 ng/mL,MPV and PDW were significantly higher in the sepsis group than in the common infection group;when PCT was at the intermediate level,MPV,PDW and P-LCR in the sepsis group were higher than those in the common infection group.In the sepsis group,the number of PLT and platelet volume were negatively correlated with PCT,and MPV,PDW and P-LCR were positively correlated with PCT.In the analysis of platelet parameters on the predictive value of 28-day prog-nosis,the area under the ROC curve of P-LCR,PDW,MPV was 0.87,0.81 and 0.79 respectively,and that of PCT was 0.97.Conclusion:There are significant differences in platelet parameters and PCT between patients with sepsis and common infections,and PCT has a higher predictive value in 28-day death.
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万方数据
