Serum chemerin and Gal-3 expression levels are valuable for predicting patients with atrial fibrillation complicated with left atrial fibrosis
Objective:To explore the predictive value of serum chemerin and Galectin-3(Gal-3)expression levels in atrial fibrillation(AF)complicated with left atrial fibrosis.Methods:A total of 138 patients with AF who underwent radiofre-quency catheter ablation for the first time in our hospital from February 2020 to June 2021 were enrolled.According to the total area of left atrium occupied by low-voltage areas(LVAS),patients were divided into LVAS＜10％group(73 cases)and LVAS≥10％group(65 cases).Serum chemerin and Gal-3 levels were detected by enzyme-linked immunosorbent as-say(ELISA),and their relationship with AF complicated with left atrial fibrosis was analyzed.The ROC curve was drawn to analyze their predictive value for AF complicated with left atrial fibrosis.Results:Persistent AF,smoking,drinking,TG,LAD,LVEF,E/A,E/e',serum chemerin,serum Gal-3 were associated with AF complicated with left atrial fibrosis(P＜0.05).Pearson correlation analysis showed that serum chemerin and Gal-3 levels were positively correlated with left atrial fibrosis in patients with AF(P＜0.01).The results of multivariate Lgistic regression analysis showed that persistent AF,decreased LAD,increased serum chemerin level and serum Gal-3 level were independent risk factors for left atrial fibrosis in patients with AF(OR＞1,P＜0.05).When the cut-off value of serum chemerin level was 147.26 ng/mL,the area under the ROC curve of predicting AF complicated with left atrial fibrosis was 0.73,and the sensitivity and specificity were 76.25％and 69.33％,respectively.When the cut-off value of serum Gal-3 level was 56.39 pg/mL,the area under the ROC curve for predicting AF complicated with left atrial fibrosis was 0.71,and the sensitivity and specificity were 74.46％and 68.29％,respectively.The area under the ROC curve for predicting AF complicated with left atrial fibrosis was 0.77.The sensitivity and specificity were 79.37％and 69.28％,respectively.Conclusion:Serum chemerin and Gal-3 levels are positively correlated with left atrial fibrosis in patients with AF complicated with left atrial fibrosis,and their levels have a good predictive value for predicting left atrial fibrosis in patients with AF complicated with left atrial fibrosis.
ChemerinGalectin-3Atrial fibrillationLeft atrial fibrosisPredictive value
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NSTL
万方数据
