Correlation between serum ESM-1,RBP-4,Lp-PLA2 levels and curative effect in cerebral infarction
Objective:To investigate the correlation between serum endothelial cell specific molecule 1(ESM-1),reti-nol binding proteins 4(RBP-4),lipoprotein-associated phospholipase A2(Lp-PLA2)and carotid atherosclerotic plaque sta-bility and neurological deficit(National Institute of Health stroke scale,NIHSS)score in patients with cerebral infarction,and the effect of each index on the efficacy.Methods:A total of 127 patients with cerebral infarction in our hospital were col-lected,and they were all given intravenous thrombolysis with recombinant tissue-type plasminogen activator(rt-PA).Ac-cording to the NIHSS score on the 7th day after thrombolysis,they were divided into the early effective group,early ineffec-tive group and early deterioration group.The correlation between each serum index and plaque stability,NIHSS score,and cerebral infarction size was examined,and the influence of each index on the curative effect and the predictive value of the curative effect were analyzed.Results:The levels of serum ESM-1,RBP-4 and Lp-PLA2 in the early deterioration group were higher than those in the early ineffective group and the early effective group,and those in the early ineffective group was higher than in the early effective group(P＜0.05).The levels of RBP-4 and Lp-PLA2 were higher in the patients with un-stable plaques than those of patients with stable plaques and patients without plaques,and those in the patients with stable plaques were higher than those without plaques(P＜0.05).The level of Lp-PLA2 was higher in the patients with severe neurological deficit than that in the patients with moderate neurological deficit and mild neurological deficit,and that in the patients with moderate neurological deficit were higher than in the patients mild neurological deficit(P＜0.05).Serum ESM-1,RBP-4 and Lp-PLA2 were higher in patients with large-sized cerebral infarction than those of patients with medium-sized cerebral infarction and patients with small-sized cerebral infarction,and those in the patients with medium-sized cere-bral infarction were higher than those with small-sized cerebral infarction(P＜0.05).Serum ESM-1,RBP-4 and Lp-PLA2 levels were negatively correlated with plaque stability,and positively correlated with NIHSS score and cerebral infarction area(P＜0.05).Serum ESM-1,RBP-4 and Lp-PLA2 levels were significantly correlated with curative effect(P＜0.05).Con-clusion:Serum ESM-1,RBP-4 and Lp-PLA2 levels may be biomarkers for evaluating carotid atherosclerotic plaque stability,NIHSS score and cerebral infarct size in patients with cerebral infarction.
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