Predictive value of procalcitonin,interleukin-6,citrulline,and intestinal trefoil factor in severe multiple injuries accompanied by acute gastrointestinal injury
Objective:To explore the predictive value of procalcitonin(PCT),interleukin-6(IL-6),citrulline,and in-testinal trefoil factor(ITF)in patients with multiple injuries complicated with acute gastrointestinal injury(ACI).Method:The clinical data of 130 patients with severe multiple injuries were analyzed and divided into ACI group(71 cases)and non-ACI group(59 cases)based on whether ACI occurred within 72 h of admission.The changes in serum PCT,IL-6,citrul-line,and ITF levels were compared between two groups.The multiple logistic regression analysis was used to identify the risk factors for AGI in patients with severe multiple injuries.Result:There were statistically significant differences(P＜0.05)in the levels of PCT,IL-6,citrulline,and ITF between the two groups on the first,third,and fifth day after injury.Multivari-ate logistic regression analysis showed that serum IL6 and citrulline were independent risk factors for AGI in patients with severe multiple injuries(all P＜0.05).Conclusion:The levels of procalcitonin,L6,and TF in patients with severe multiple injuries complicated by ACI significantly increase,while the levels of citrullinc gradually decrease and then increase.These indicators are risk factors affecting the occurrence of AGI.
Severe multiple injuriesAcute gastrointestinal injuryCorrelation analysis
NETL
NSTL
万方数据
