Clinical significance of miR-2467 and miR-96-5p in gestational diabetes mellitus
Objective:To investigate the clinical significance of microRNA-2467(miR-2467)and miR-96-5p in gesta-tional diabetes mellitus(GDM).Methods:A total of 108 inpatients with GDM were included as the GDM group,and 82 pregnant women with normal glucose tolerance during prenatal examinations were included as the control group.The relative expression levels of miR-2467,miR-96-5p,fasting plasma glucose(FPG),2-h postprandial blood glucose(2hPG),hemo-globin A1c(HbA1c)and homeostasis model assessment-insulin resistant index(HOMA-IR)were compared between the two groups,and the correlation between miR-2467,miR-96-5p and the above blood glucose indicators was analyzed.Logistic multivariate regression modeling was used to analyze the risk factors of GDM,and subject working characteristic curve was drawn to analyze the area under the curve(AUC)of miR-2467 and miR-96-5p to evaluate GDM.Results:The expression levels of serum miR-2467,FPG,2hPG,HbA1c and HOMA-IR in GDM group were higher than those in control group,and the expression of miR-96-5p was lower than that in control group(all P＜0.05).Pearson linear correlation analysis showed that the expression of serum miR-2467 was positively correlated with FPG,2hPG,HbA1c and HOMA-IR,and the expression of serum miR-96-5p was negatively correlated with the above 4 indicators of blood glucose(all P＜0.05).Logistic multiple regression analysis showed that the increase of BMI ≥1.73 kg/m2 in early pregnancy,BMI increase ≥ 4.88 kg/m2 in the second trimester,family history of diabetes and miR-2467 ≥3.44 were risk factors for GDM.miR-96-5p≥ 1.95 was a pro-tective factor for GDM(P＜0.05).The AUC of serum miR-2467 combined with miR-96-5p for evaluating GDM was 0.865,with sensitivity and specificity of 91.50％,and 81.50％,respectively.Conclusion:There is a correlation between miR-2467,miR-96-5p and blood glucose index and HOMA-IR in GDM,which has certain evaluation significance for GDM.
Gestational diabetes mellitusmiR-2467miR-96-5pmicroRNABlood glucoseHomeostasis model assessment-insulin resistant index
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