Fluid-attenuated inversion recovery sequence high signal vascular sign could predict the short-term neurological function prognosis in patients with acute cerebral infarction
Objective:To investigate the predictive value of high signal vascular sign of fluid-attenuated inverse recovery sequence(Flair)combined with neutrophil count in short-term neurological prognosis in patients with acute cerebral infarc-tion(ACI).Methods:A total of 96 patients with ACI diagnosed by head magnetic resonance were selected and scored by the National Institutes of Health Neurological Impairment Scale(NIHSS)at admission.They were divided into mild group(41 cases),moderate group(30 cases)and severe group(25 cases)according to the NIHSS scores.All patients were examined by magnetic resonance imaging,and Flair high signal vascular signs were scored to analyze the relationship between Flair high signal vascular signs,neutrophil counts and short-term neurological function prognosis in ACI patients.At 6th month after the onset of the disease,the patients were divided into a good prognosis group(81 cases)and a poor prognosis group(15 cases)by using the modified Rankin scale(mRS)score.Results:The proportion of patients aged ≥60 years and hav-ing history of hypertension and coronary heart disease,NIHSS score at admission,lesion diameter and neutrophil count in severe group were higher than those in moderate and mild groups,while the score of Flair high signal vascular sign in severe group was lower than that in moderate and mild groups(all P＜0.05).Multivariate logistic regression analysis showed that Age ≥60 years,history of hypertension and coronary heart disease,NIHSS score≥12 points at admission(OR=1.267,95％C1:1.140-1.409),elevated neutrophil count(OR=1.719,95％CI:1.351-2.188),Flair high signal vascular score＜4.76 points(OR=2.190,95％C1:1.437-3.338)were independent risk factors for neurological impairment in ACI patients(all P＜0.05).Flair high signal vascular scores were lower and neutrophil counts were higher in the poor prognosis group(all P＜0.05).Receiver operating characteristic(ROC)curve was drawn with poor prognosis as the dependent varia-ble.The results showed that when the cut-off value of Flair high signal vascular sign score was 4.76,the area under the ROC curve was 0.76(95％C1:0.745-0.826),and the sensitivity and specificity were 70.33％and 64.33％,respectively,for predicting the short-term neurological function prognosis in ACI patients.When the cut-off value of neutrophil count was 5.82 x109/L,the area under the ROC curve was 0.74(95％CI:0.723-0.814),and the sensitivity and specificity were 77.56％and 63.24％,respectively,for predicting the short-term neurological prognosis of ACI patients.The combined use showed the area under the ROC curve was 0.81(95％C1:0.839-0.876),and the sensitivity and specificity were 80.25％and 63.46％,respectively,for predicting the short-term neurological function prognosis in ACI patients.Conclusion:Decreased Flair high signal vascular sign score and increased neutrophil count are independent risk factors for short-term neurological function prognosis in patients with ACI,and have important reference value for evaluating patient prognosis.
Fluid-attenuated inversion recovery sequence high signal vascular signNeutrophilsAcute cerebral infarc-tionNeurological functionShort-term prognosis
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