Incidence of carotid atherosclerosis in elderly diabetic patients with asymptomatic hyperuricemia and its influencing factors
Objective:To investigate the incidence of carotid atherosclerosis in elderly diabetic patients with asympto-matic hyperuricemia(HUA),and to analyze its influencing factors.Methods:A total of 168 elderly diabetic patients with a-symptomatic HUA were selected as the research objects.The incidence of carotid atherosclerosis was calculated and the cor-relation between uric acid(UA)level and carotid atherosclerosis was analyzed.Logistic regression was used to analyze the influencing factors of carotid atherosclerosis.Results:The incidence of carotid atherosclerosis in elderly diabetic patients with asymptomatic HUA was 46.43％(78/168),of which 51.28％(40/78)were male and 48.72％(38/78)were female.The incidence of carotid atherosclerosis in male elderly diabetic patients with asymptomatic HUA increased with the increase of UA level(P＜0.05),and the differences in carotid intima mediathickness(IMT)and carotid plaque thickness were statistically significant among all elderly diabetic patients with asymptomatic HUA with different UA concentrations(all P＜0.05).Pearson correlation analysis revealed that UA level was positively correlated with carotid atherosclerotic plaque thick-ness and IMT(r=0.490,r=0.372,all P＜0.05).Logistic regression equation analysis showed that age,duration of diabetes,total cholesterol(TC),triglycerol(TG),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),glycosylated hemoglobin(HbA1c),and UA were important factors in the development of carotid atherosclerosis in elderly diabetic patients with asymptomatic HUA(all P＜0.05).Conclusion:Carotid atherosclerosis has a higher incidence in elderly diabetic patients with asymptomatic HUA.It is related to the patient's age,diabetes course,TC,TG,HDL-C,LDL-C,HbA1c,UA and other factors.Controlling blood sugar,blood lipids,and UA levels helps prevent and reduce the occurrence of carotid atherosclerosis.
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