Diagnostic and therapeutic strategies for mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes
Mitochondrial encephalomyopathy,lactic acidosis,and stroke-like episodes(MELAS)represent the most common clinical subtype of mitochondrial disorders.The clinical manifestations of MELAS include stroke-like episodes,headaches,epilepsy,and muscle weakness while also exhibiting significant heterogeneity through multi-system presentations.Diagnosis necessitates a comprehensive approach involving detailed medical history,accurate family history assessment,and pathological,biochemical,and genetic testing results.Treatment requires a multidisciplinary approach,encompassing phar-macotherapy and nutritional and exercise interventions.This article provides an overview of the diagnostic and therapeutic strategies for MELAS to aid clinicians in gaining a comprehensive understanding of this condition and facilitating early diagno-sis and standardized treatment to improve the long-term prognosis of patients.
NETL
NSTL
万方数据
