The value of serum bone morphogenetic protein 9 and growth differentiation factor 15 in diagnosis and prognosis evaluation of sepsis
Objective:To explore the expression of serum bone morphogenetic protein 9(BMP9)and growth differentia-tion factor 15(GDF15)in the sepsis patients and their value in the diagnosis and prognosis evaluation of sepsis.Methods:Totally,30 patients with sepsis were selected as the sepsis group,31 severe non-septic patients were selected as the non-sep-tic group,and 23 adults undergoing physical examination during the same period were selected as the healthy control group.The outcome of sepsis patients was followed up for 28 days.Sepsis patients were divided into the survival group(16 cases)and the death group(14 cases).The general data,clinical indicators and BMP9 and GDF15 levels were analyzed and compared.The risk factors of sepsis onset and prognosis were analyzed by Logistic regression.The value of BMP9 and GDF15 in the diagnosis and prognosis of sepsis was evaluated by the area under the receiver operating characteristic(ROC)cure.Results:There were statistically significant differences in the levels of BMP9 and GDF15 among the three groups(P＜0.05).Compared with the non-sepsis and control groups,BMP 9 expression was significantly increased in the sepsis group(P＜0.05).Compared with the control group,the GDF 15 expression was significantly increased in the sepsis group.The levels of BMP9 and GDF15 were significantly higher in the death group than those in the survival group(P＜0.05).BMP9 was an independent risk factor for sepsis onset,and GDF15 was an independent influencing factor for death in sepsis patients.The AUC of BMP9 combined with C reactive protein(CRP)for the diagnosis of sepsis was 0.845,specificity 83.9％,sensitivity 73.3％,the diagnostic efficacy was comparable to the sequential organ failure(SOFA)score(AUC 0.809,specificity 83.9％,sensitivity 70.0％).The AUC of GDF15 combined with NLR for the prognosis of sepsis patients was 0.898,specificity 80％,sensitivity 100％,the predictive efficacy was comparable to the Acute Physical and Chronic Health Status Assessment(APACHE Ⅱ)score(AUC 0.687,specificity 93.9％,sensitivity 53.3％).Conclusion:The expression of BMP9 and GDF15 is significantly increased in sepsis patients.BMP 9 combined with CRP has a high value in sepsis diagnosis evaluation.GDF 15 combined with NLR has a high prognosis prediction efficacy in patients with sepsis.
SepsisBone morphogenetic protein 9Growth differentiation factor 15
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