Combined detection of serum high mobility group box 1 and soluble triggering receptor expressed on myeloid cells-1 has predictive value in sepsis complicated with acute kidney injury
Objective:To explore the diagnostic value of serum high mobility group box 1(HMGB1)and soluble trigge-ring receptor expressed on myeloid cells-1(sTREM-1)in sepsis complicated with acute kidney injury(AKI).Method:A total of 120 patients with sepsis were divided into AKI group(47 cases)and non-AKI group(73 cases).Serum creatinine,C-reactive protein,cystatin C,HMGB1 and sTREM-1 levels in 2 groups were detected by enzyme-linked immunosorbent as-say(ELISA).Serum white blood cell count and hemoglobin level were detected in 2 groups.The lactic acid level of the two groups was detected by spectrophotometry.The levels of albumin in 2 groups were detected by immunoturbidimetry.Sequen-tial organ failure score(SOFA)and Acute Physiological and Chronic Health status Assessment(APACHEⅡ)scores were performed in both groups.The two groups of indicators were compared,and univariate analysis and multivariate Logistic regression were used to analyze the independent influencing factors of patients with sepsis complicated with AKI.Receiver operating characteristic(ROC)curve was plotted to evaluate the predictive value of each indicator.Results:Serum creati-nine,cystatin C,lactic acid,HMGB1,sTREM-1,SOFA score and APACHE Ⅱ score were independent risk factors for AKI in sepsis patients(all P＜0.05).The area under ROC curve(AUC)of HMGB1 combined with sTREM-1 in diagnosing sep-tic AKI was 0.879,which was better than that of HMGB1 and sTREM-1 alone(AUC was 0.778 and 0.823,respectively).Conclusions:Serum HMGB1 and sTREM-1 are independent risk factors for AKI in patients with sepsis.Combined detection of HMGB1 and sTREM-1 is superior to single detection in the diagnosis of AKI in patients with sepsis,and can be used as sensitive indicators to evaluate the condition of these patients.
High mobility group box 1Soluble triggering receptor expressed on myeloid cells-1SepsisAcute kidney injury
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