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慢性阻塞性肺疾病前期研究进展

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慢性阻塞性肺疾病(简称慢阻肺)是不完全可逆的持续气流受限疾病.慢阻肺的发病是一个漫长的过程.如果能在慢阻肺尚未发病时提前发现最终有可能发展为慢阻肺的人群,如有呼吸道症状、结构异常或功能异常但1秒钟用力呼气容积/用力肺活量(FEV1/FVC)尚正常的人群,即慢阻肺前期人群,将有助于提前开展病因预防即危险因素干预,以及早期治疗干预,以减缓疾病的进展过程.本文针对慢阻肺前期潜在指标的相关研究进行论述,并提出慢阻肺前期未来的研究方向.
Research progress on pre-chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease(COPD)is a disease presenting incompletely reversible and persis-tent airflow obstruction,which needs a long time to be developed.If individuals who would develop COPD finally could be i-dentified before the disease occurs,such as those with respiratory symptoms,structural or functional abnormalities but normal forced expiratory volume in one second(FEV1)/forced vital capacity(FVC)at present(pre-COPD),interventions regard-ing risk factors and treatment in early stage could be implemented to slow down the disease progression.In this article we dis-cussed studies relevant to potential indicators for pre-COPD and proposed the research direction of pre-COPD in the future.

Chronic obstructive pulmonary diseasePre-chronic obstructive pulmonary disease

樊静、方利文、陈亚红

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北京大学第三医院呼吸与危重症医学科,北京 100191

中国疾病预防控制中心慢性非传染性疾病预防控制中心,北京 100050

慢性阻塞性肺疾病 慢性阻塞性肺疾病前期

北京市科技新星计划交叉合作课题海淀转化专项基金院队列项目(B类)国家自然科学基金重大项目

20220484157HDCXZHKC2021206BYSYDL202101382090014

2024

内科急危重症杂志
华中科技大学同济医学院

内科急危重症杂志

CSTPCD
影响因子:0.947
ISSN:1007-1024
年,卷(期):2024.30(5)