Expression of SLC3A2 in chronic obstructive pulmonary disease and its relationship with inflammation
Objective:To investigate the role of solute carrier family 3 member 2(SLC3A2)in the pathogenesis of chro-nic obstructive pulmonary disease(COPD).Methods:A total of 72 patients with stable COPD were included in the COPD group,and 67 healthy subjects served as the control group.Peripheral venous blood was collected from both groups,and neutrophils were isolated by density gradient centrifugation and red cell lysis.SLC3A2 levels in peripheral blood were detected by Western blotting and interleukin-8(IL-8)in plasma was detected by enzyme-linked immunosorbent assay(ELISA).At the same time,the pulmonary function indexes,including forced expiratory volume in the first second(FEV,)and forced vital capacity(FVC)were determined.The correlation between SLC3A2 and IL-8,FEV1/FVC,FEV1％predic-ted values was analyzed.Results:The levels of SLC3A2 and IL-8 in peripheral blood neutrophils in COPD group were higher than those in control group(all P＜0.01).SLC3A2 was positively correlated with IL-8(r=0.45,P＜0.01),and nega-tively correlated with FEV1/FVC and FEV1％predicted values(r=-0.42,-0.45,all P＜0.01).Conclusion:SLC3A2 may participate in the occurrence of COPD by inflammatory response,and SLC3A2 may become a clinical inflammatory marker and a therapeutic target.
Chronic obstructive pulmonary diseaseSolute carrier family 3 member 2 proteinAmino acid metabolismInflammatory pathogenesis
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