Clinical efficacy of Nintedanib in the treatment of connective tissue-associated interstitial pneumonia
Objective:To evaluate the efficacy of Nintedanib combined with conventional treatment for connective tissue-associated interstitial pneumonia(CTD-ILD).Methods:A total of 102 patients with CTD-ILD were collected and divided into conventional treatment group(50 cases)and Nintedanib combined treatment group(52 cases)for 6 months according to different clinical treatment plans.The changes of clinical symptoms,lung functions,high resolution CT scores and serum cytokine levels were compared before and 6 months after treatment in 2 groups.Results:The serum cytokines and lung high resolution CT scores in Nintedanib combined treatment group were significantly lower than those before treatment,and the lung function was significantly improved(all P＜0.05).Conclusion:Nintedanib combined with conventional glucocorticoid anti-inflammatory therapy can reduce serum cytokine levels in CTD-ILD patients,reduce inflammation in vivo,improve lung function,and help delay the progression of pulmonary fibrosis in CTD-ILD patients.
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