CURB-65 score combined with S100A8 predicts hospital death in elderly patients with community acquired pneumonia
Objective:To assess the clinical value of CURB-65 score combined with S100 calcium-binding protein A8(S100A8)in predicting death during hospitalization in elderly patients with community acquired pneumonia(CAP).Methods:The clinical data of 276 elderly patients with CAP were collected through the inpatient electronic medical record system,and they were divided into a death group(64 cases)and a survival group(212 cases)according to their survival status during hospitalization.Multifactorial logistic regression was used to screen the independent risk factors for death during hospitalization in CAP patients,and receiver operating characteristic(ROC)curves were used to assess the clinical value of the CURB-65 score combined with S100A8 in predicting death during hospitalization in elderly CAP patients.Results:Uni-variate analysis showed that the proportion of patients with age＞70 years,altered consciousness,and blood lactate,IL-6,S100A8 levels,APACHE Ⅱ and CURB-65 scores were higher in the death group than those in the survival group(all P＜0.05).Multifactorial logistic regression analysis showed that age＞70 years,S100A8＞109 pg/mL,APACHE Ⅱ score＞25,and CURB-65＞2.85 were independent risk factors for all-cause mortality during hospitalization in elderly patients with CAP.ROC curves showed that the area under the curve of the CURB-65 score combined with the S100A8 predicting death during hospitalization in elderly patients with CAP was higher than that of the single CURB-65 score and the S100A8,which had the highest predictive performance.Conclusion:CURB-65 score and S100A8 are closely related to the clinical prognosis of elderly CAP patients during hospitalization,and the combination of these scores can predict the risk of all-cause mortality during hospitalization.
Community acquired pneumoniaCURB-65 scoreS100 calcium binding protein A8
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NSTL
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