Level of T cell subsets in patients with aortic dissection can predict the 30-day survival status
Objective:To investigate the relationship between T cell subsets and 30-day survival status in patients with aortic dissection.Methods:The clinical data of 184 patients with aortic dissection who underwent surgical treatment were collected.The patients were divided into survival group(149 cases)and death group(35 cases)according to their survival status 30 days after admission,and T cell subsets(CD3+,CD3+CD4+,CD3+CD8+)in the two groups were compared.Multiple Logistic regression was used to analyze the influencing factors of death at 30 days after admission.The predictive value of CD3+,CD3+CD4+,CD3+CD8+T cells was analyzed by the ROC curve.Results:Among 184 patients with aortic dissection,35(19.02％)died of all causes within 30 days after admission.The proportions of Stanford type A,hypoxemia,hypertension,systolic and diastolic blood pressure on admission,and CD3+CD8+T cells in the death group were higher than those in the survival group,and the levels of CD3+and CD3+CD4+T cells in the death group were lower than those in the survival group(all P＜0.05).Logistic regression analysis showed that CD3+CD8+,Stanford A type,hypoxemia and hyper-tension were risk factors for 30-day mortality in patients with aortic dissection,and CD3+,CD3+CD4+T cells were protec-tive factors(all P＜0.05).The area under curve(AUC)of CD3+,CD3+CD4+and CD3+CD8+T cells were 0.731(95％CI=0.644-0.819),0.801(95％CI=0.726-0.875)and 0.824(95％CI=0.731-0.918)respectively in predicting the death of patients with aortic dissection at 30th day.Conclusion:The levels of CD3+,CD3+CD4+and CD3+CD8+T cell subsets in patients with aortic dissection are correlated with the survival status 30 days after admission,and the three factors together with Stanford type A,hypoxemia and hypertension affect the 30-day survival status of patients.
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