Inflammation-new targets for the treatment of vasospastic angina
Vasospastic angina(VSA),characterized by coronary artery spasm,significantly affects patient health.While conventional treatments like nitroglycerin and calcium channel blockers benefit most of patients with VSA,they often prove ineffective for refractory VSA,leading to poor outcomes.Recent studies underscore the pivotal role of inflammation in VSA pathogenesis,particularly via allergic reactions,myocarditis,and inflammation of adjacent tissues.Inflammatory biomarkers and advanced imaging techniques have emerged as valuable tools for diagnosing VSA,offering fresh perspectives for clinical practice.Additionally,anti-inflammatory and immune-modulating therapies are gaining traction for their potential to enhance outcomes in refractory VSA patients.Future research should focus on the dynamic alterations of inflammatory cells and mediators in VSA,as well as the precise evaluation of the inflammatory status in the heart and coronary arteries,to develop more personalized treatment approaches.Overall,inflammation-targeted therapies present promising new avenues for VSA management,with the potential for significant advancements in clinical applications.
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