Serum GDF-15 and sST2 can diagnose the occurrence of myocardial injury in patients with acute carbon monoxide poisoning
Objective:To investigate the diagnostic value of serum growth differentiation factor-1 5(GDF-15)and solu-ble growth stimulating gene 2(sST2)for myocardial injury in patients with acute carbon monoxide poisoning(ACOP).Methods:Totally,82 hospitalized patients with ACOP were selected as the research subjects,and were divided into myocar-dial injury group(33 cases)and non-myocardial injury group(49 cases)based on their cTnl levels at 3 h after admission.The fasting venous blood was collected from all patients upon admission,and enzyme-linked immunosorbent assay(ELISA)was used to detect serum GDF-15 and sST2 levels in two groups.The fully automated biochemical analyzer was used to detect the levels of myocardial enzymes[creatine kinase(CK),creatine kinase isoenzyme(CK-MB)]and the differences between groups were compared.The Pearson method was used to analyze the correlation between serum GDF-15,sST2 and myocardial enzyme levels.Receiver operating characteristic(ROC)curve was used to analyze serum GDF-15 and sST2 for the diagnos-tic value of myocardial injury in ACOP patients.Logistic regression analysis was used to evaluate the influencing factors of myocardial injury in ACOP patients.Results:The proportion of patients with a history of smoking and the levels of serum GDF-15,sST2,CK,and CK-MB in the myocardial injury group were significantly higher than those in the non-myocardial injury group(all P＜0.05).Pearson correlation analysis showed that serum GDF-15 and sST2 levels in ACOP patients were positively correlated with CK and CK-MB levels(all P＜0.05).The areas under the curve(AUC)of serum GDF-15,sST2 levels,and their combined diagnosis of ACOP patients with myocardial injury were 0.854,0.885,and 0.945,respectively.Logistic analysis showed that serum GDF-15,SST2,CK,CK-MB levels,and smoking history were influencing factors for myocardial injury in ACOP patients(P＜0.05).Conclusion:Serum GDF-15 and sST2 levels are significantly elevated in pa-tients with ACOP myocardial injury,and are independent influencing factors for the occurrence of myocardial injury in ACOP patients.The combined detection of the two has high diagnostic value for the occurrence of myocardial injury in ACOP patients.
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