Serum S100A8/A9 level has predictive value for early neurological deterioration in patients with acute ischemic stroke after rt-PA intravenous thrombolysis
Objective:To investigate the relationship between serum S100 calbindin A8/A9 complex(S100A8/A9)level and early neurological deterioration(END)in patients with acute ischemic stroke(AIS)after intravenous thrombolysis with recombinant human tissue plasminogen activator(rt-PA).Methods:A total of 180 AIS patients who received rt-PA intravenous thrombolysis were selected as the research objects and categorized into 37 in the END group and 143 in the non-END group.Serum S100A8/A9 levels were assayed using enzyme-linked immunosorbent assay(ELISA)and factors influencing the occurrence of END were analyzed.Receiver operating characteristic(ROC)curves were used to analyze the predictive value of S100A8/A9 for the occurrence of END.Results:Patients with AIS with a history of atrial fibrillation and hypertension were more likely to have END(P＜0.05).The time from onset to thrombolysis was longer,and the score of National Institutes of Health Stroke Scale(NIHSS)and the serum S100A8/A9 level in the END group was significantly high-er than in the non-END group(P＜0.05).ROC curve analysis showed that the AUC of serum S100A8/A9 predicting END after rt-PA intravenous thrombolysis in AIS was 0.791(0.692-0.891),when the best diagnostic cut-off value was 1.807 mg/mL,the corresponding sensitivity was 78.4％and the specificity was 79.0％.The history of atrial fibrillation,history of hypertension,NIHSS score,and S100A8/A9 were the influencing factors for the occurrence of END(P＜0.05).Conclusion:S100A8/A9 can be used as an auxiliary index to determine whether END occurs after intravenous thrombolysis in AIS patients.
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