Combinded detection of serum S100β,Aβ and NSE to improve the predictive efficacy of establishing cerebral collat-eral circulation in acute cerebral infarction
Objective:To explore the value of combined detection of serum calcium binding protein β(S100β),β-am-yloid protein(Aβ)and neuron specific enolase(NSE)levels in predicting the establishment of cerebral collateral circulation in patients with acute cerebral infarction(ACI).Methods:A total of 132 patients with ACI were selected as the disease group,and 150 people receiving healthy physical examination were selected as the control group.The establishment of collat-eral circulation in the disease group was judged by digital subtraction angiography(DSA).According to the DSA examination results,the grade 0 patients were classified as non-collateral circulation establishment group(51 cases),and the grade 1-4 patients were classified as collateral circulation establishment group(81 cases).The levels of serum S100β,Aβ and NSE in the two groups were measured by enzyme-linked immunosorbent assay,and the receiver operating characteristic(ROC)curve was used to analyze the predictive value of single and combined detection of each index for the establishment of collateral circulation.Results:The levels of serum S100β,Aβ and NSE in the disease group were higher than those in the control group(all P＜0.05).The DSA results showed that 81 out of 132 patients(61.36％)had collateral circulation establish-ment,and the levels of serum S100β,Aβ and NSE in the collateral circulation establishment group were lower than those in the non-collateral circulation establishment group(all P＜0.05).The ROC results showed that the sensitivity and area under the curve(AUC)of the combined detection of serum S100β,Aβ and NSE levels in determining the establishment of collateral circulation in ACI patients were higher than those of the three separate tests(all P＜0.05),but there was no significant difference in specificity between combined detection and three separate tests(all P＞0.05).Conclusion:The levels of serum S100β,Aβ and NSE in ACI patients are higher than those in healthy people,and they are related to the establishment of cerebral collateral circulation.The combined detection of the three is more effective in predicting the estab-lishment of cerebral collateral circulation in ACI patients.
Acute cerebral infarctionlCerebral collateral circulationCalcium binding protein ββ-amyloid proteinNeuron specific enolase
NETL
NSTL
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