Mechanisms and therapeutic strategies of ferroptosis in atrial fibrillation
Atrial fibrillation(AF),due to its high incidence and severe complications such as thrombosis and heart failure,poses a significant healthcare burden on society.Currently,the treatment options for AF are limited.Ferroptosis,an iron-dependent programmed cell death characterized by iron metabolism disorder,lipid peroxidation,and reactive oxygen species(ROS)accumulation,has been linked to various diseases.Emerging evidence suggests that ferroptosis can serve as a therapeutic target to reduce the occurrence of AF,which has been validated in animal models.This article explores the potential role of ferroptosis in AF treatment,providing new ideas for the development of novel therapies.
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