铁死亡引发心房颤动的作用机制及治疗策略
Mechanisms and therapeutic strategies of ferroptosis in atrial fibrillation
王媛媛 1孙家正 2柳湘洁1
作者信息
- 1. 华中科技大学同济医学院附属梨园医院老年科,湖北武汉 430000
- 2. 华中科技大学同济医学院附属梨园医院呼吸内科,湖北武汉 430000
- 折叠
摘要
心房颤动(AF)由于其高发病率和由其产生的严重并发症,如血栓形成和心力衰竭,给社会带来了严重的医疗负担.目前对于AF的治疗有限.铁死亡是一种铁依赖的程序性细胞死亡方式,其特征是铁代谢紊乱、脂质过氧化和活性氧(ROS)聚积,与多种疾病有关.新证据表明,铁死亡可以作为减少AF发生的治疗靶点,已在动物模型中得到验证.本文探讨铁死亡在AF治疗中的潜在作用,为开发新疗法提供新思路.
Abstract
Atrial fibrillation(AF),due to its high incidence and severe complications such as thrombosis and heart failure,poses a significant healthcare burden on society.Currently,the treatment options for AF are limited.Ferroptosis,an iron-dependent programmed cell death characterized by iron metabolism disorder,lipid peroxidation,and reactive oxygen species(ROS)accumulation,has been linked to various diseases.Emerging evidence suggests that ferroptosis can serve as a therapeutic target to reduce the occurrence of AF,which has been validated in animal models.This article explores the potential role of ferroptosis in AF treatment,providing new ideas for the development of novel therapies.
关键词
铁死亡/心房颤动/氧化应激/靶向治疗Key words
Ferroptosis/Atrial fibrillation/Oxidative stress/Targeted therapy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据