In order to determine the cardiac safety of castor oil in patients with heart failure combined with con-stipation,rats were divided into a normal control group and an adriamycin-induced dilated cardiomyopathy group by using animal experiments,the effects of dimethylsulfoxide(DMSO)and DMSO+castor oil on electrocardiogram(ECG),left ventricular conduction velocity and conduction dispersion degree of isolated perfused hearts of normal rats and adriamycin-induced dilated cardiomyopathy rats were recorded and analyzed by multi-channel electrical mapping technique.The results showed that castor oil had no significant effect on electrocardiogram(ECG),left ven-tricular conduction velocity and conduction dispersion in normal rats and adriamycin-induced dilated cardiomyopa-thy rats.Therefore,castor oil did not trigger arrhythmia in normal rats and adriamycin-induced dilated cardiomyopa-thy rats,and the use of castor oil in patients with heart failure combined with constipation was safe and effective.
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