Effect of Local Base-pair Helical Parameters of mRNA Tertiary Structure on Protein Folding Rate
To explore the mechanism underlying the effect of local base-pair helical parameters on the protein folding rate,this study collected 100 proteins with experimental folding rates for research.The mRNA tertiary structure data of each protein were obtained computationally,and the local base-pair helical parameters were filtered out.The correlation between these parameters and the protein folding rate was studied in depth.The selected proteins were grouped according to the folding type and secondary structure.Further,the study analyzed the differences in the effects of these parameters on the folding rates of different classes of proteins.The results show that the protein folding rate is correlated with six parameters of X-disp,Y-disp,h-Rise,Incl(η),Tip,and h-Twist to varying degrees,which indicates that the local base-pair helical parameters of mRNA tertiary structure play an important role in regulating the protein folding rate.
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