RESEARCH PROGRESS OF CKS1B IN THE MECHANISM OF DRUG RESISTANCE IN LUNG CANCER
Lung cancer is one of common malignant tumors in the world,which is a great threat to people's health and life.Chemotherapy is still the main treatment method for most advanced patients,but drug resistance is the main reason for treatment failure.How to overcome tumor drug resistance is the direction of future research.CDC28 protein kinase regulatory subunit 1 B(CKS1 B),a member of the CKS family,can combine with CDK catalytic subunit to regulate cell cycle function.In re-cent years,studies have found that CKS1 B is a cancer-promoting factor in a variety of tumors,which can promote the occur-rence of tumors and is closely related to poor prognosis of patients.In this review,the mechanism of CKS1B on lung cancer cells and its therapeutic target were reviewed.
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