首页|精神发育迟滞伴精神障碍患者的外科治疗手段及疗效

精神发育迟滞伴精神障碍患者的外科治疗手段及疗效

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精神发育迟滞(mentalretardation,MR)患者常表现为智力低下和社会生活适应困难,也可伴有精神障碍、行为障碍、以及情感障碍等其他症状。MR在我国城乡精神疾病中占比较大,属于预防与治疗的重点疾病,是一种难治性精神疾病。精神发育迟滞患病人群年龄较小,在幼年即可发病,相关症状往往伴随终生。精神发育迟滞主要由遗传因素及环境因素导致,患者存在多种躯体和神经系统疾病,伴有行为异常、社会适应能力差等症状。MR可根据IQ值及严重程度分为轻、中、重、极重四级,常用婴儿-初中生社会生活能力量表及格塞尔发展量表、创伤筛选问卷、智力残疾儿童学习能力评估表、简明曼彻斯特生存质量评定量表进行评估。目前常用的外科治疗方案有立体定向毁损术、脑深电刺激术、胼胝体切开术、双侧内囊前肢切开术和杏仁核切开术、间充质干细胞移植等。本文将伴精神障碍的MR疾病特征、外科治疗手段及疗效进行综述。
THE SURGICAL TREATMENT MEANS AND CURATIVE EFFECT OF MENTAL RETARDATION ACCOMPANIED BY MENTAL DISORDERS
Mental retardation(MR)patients often exhibit intellectual disability and difficulties in adapting to social life.They may also have other symptoms such as mental disorders,behavioral disorders,and emotional disorders.MR also accounts for a significant proportion of mental illnesses,both in urban and rural areas in our country,making it a key disease in terms of prevention and treatment.The onset of mental retardation occurs at an early age,with symptoms often persisting throughout life.It is primarily caused by genetic and environmental factors,and patients may have various physical and neurological diseases,along with symptoms such as abnormal behavior and poor social adaptability.MR can be classified into four levels(mild,moder-ate,severe,and profound)based on IQ scores and severity.Common assessment tools include the Infant-Child Social Life Abili-ty Scale,Gesell Development Scale,Trauma Screening Questionnaire,Intellectual Disability Children's Learning Ability As-sessment,and Brief Manchester Quality of Life Assessment.Currently used surgical treatment options include stereotactic abla-tion,deep brain stimulation,corpus callosotomy,bilateral anterior capsulotomy,amygdalohippocampectomy,and mesenchymal stem cell transplantation.This article will provide an overview of the treatment principles,mechanisms,and current efficacy of these surgical approaches.

mental retardationmental disordersstereotactic techniques

李宸辉、易伟

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武汉大学第一临床学院,湖北 武汉 430071

武汉大学人民医院神经外科,湖北 武汉 430060

精神发育迟滞 精神障碍 立体定位技术

2024

内蒙古医科大学学报
内蒙古医学院

内蒙古医科大学学报

CSTPCD
影响因子:1.512
ISSN:2095-512X
年,卷(期):2024.46(2)