RESEARCH PROGRESS ON PEPTIDE-BASED FUSION INHIBITORS TARGETING THE 6-HB CORE OF SARS-CoV-2 MEMBRANE FUSION PROCESS
Corona virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has profoundly affected human health.Meanwhile,the continuously arising of SARS-CoV-2 has been posting a con-tinuing threat to public health safety globally.Therefore,it is urgent to develop anti-SARS-CoV-2 agents.SARS-CoV-2 en-velope forms a six-helix bundle(6-HB)structure during the membrane fusion process with the host cell.A series of peptide-based fusion inhibitors have been successfully obtained by targeting the 6-HB or the HR1/HR2 regions composing 6-HB.This paper reviewed the structure-activity relationship of the SARS-CoV-2 6-HB and the design ideas and retrofitting meth-ods of peptide-based fusion inhibitors.We hope that this review will provide new research insights for the development of an-ti-SARS-CoV-2 agents.
NETL
NSTL
万方数据
